Depends what you're replacing them with (footballers, lol).
If we want to play wingbacks (please God, no) then whoever replaces Jackson has to have some proper output and I'd argue Wolfe either needs to seriously step up or be replaced as well.
If it's a three man midfield(ish) like today then what are you after alongside the two Brazilians, if it's just another dog of war then it doesn't help us that much. It'd have to be someone who can either score and/or create, surely.
You'd need to replace the keeper too, they're all diabolical.
And then you have the issue of every single sub being fucking shit.