My own maths, so the odd one may be wrong.
Hours between kick offs
99 Fulham
96 Newcastle
79.5 Man U
75.5 Liverpool
75 Southampton
72.5 Arsenal
72 Sheffield United
70.75 Spurs
54 Leeds, Burnley
51.75 Brighton, West Ham
50.5 Villa
49.5 WBA
48.75 Wolves
48 Palace, Chelsea, Man C, Everton
Biggest delta between opponents rest
Man U over Wolves 30.75 hours
Fulham over Spurs 28.25 (but Spurs still have nearly 3 days between games)
Southampton over West Ham 23.25
It's not the rest which is the big disadvantage, it's the disparity between the 2 teams